acute and chronic in vivo effects of exposure to nicotine and propylene glycol from an E-cigarette on mucociliary clearance in a murine model

Introduction:
This text discusses a study examining the effects of acute and chronic exposure to electronic cigarette (E-cigarette) emissions on mucociliary clearance (MCC) in a murine model. The study found that chronic, but not acute, exposure to two of the major constituents of E-cigarettes, propylene glycol (PG) alone and in combination with nicotine, have significant effects on MCC in this murine model.

Key Points:

* The study exposed mice to E-cigarette emissions for 20 minutes per day for one or three weeks.
* MCC was measured by aspiration of a radioisotope technetium-labeled sulfur colloid (99mTc-SC) aerosol and recording retention at 0 hours and 6 hours post-aspiration.
* Chronic exposure to 0% N/PG stimulated MCC, whereas PG plus 2.4% N significantly blunted the MCC response to PG plus 0% N.
* Serum cotinine levels, a marker for nicotine exposure, were significantly higher in mice exposed to 2.4% N/PG compared to control mice.
* There were no gross histological differences in the tracheas of mice exposed to E-cigarette emissions.
* The study suggests that chronic, but not acute, exposure to E-cigarette constituents have significant effects on MCC in a murine model.
* The study highlights the need for further research on the potential risks to the MCC apparatus from chronic exposure to E-cigarette emissions.

Main Message:
The main message of this text is that chronic exposure to E-cigarette emissions, specifically PG and nicotine, can have significant effects on MCC in a murine model. This finding suggests that there may be potential risks to the MCC apparatus from chronic exposure to E-cigarette emissions, and further research is needed to better understand these risks. additionally, the study highlights the importance of considering the potential long-term health effects of E-cigarette use, particularly in light of their increasing popularity.

Laube, Beth L., Nima afshar-Mohajer, Kirsten Koehler, Gang Chen, Philip Lazarus, Joseph M. Collaco, and Sharon a. McGrath-Morrow. “acute and Chronic in Vivo Effects of Exposure to Nicotine and Propylene Glycol from an E-Cigarette on Mucociliary Clearance in a Murine Model.” Inhalation Toxicology 29, no. 5 (april 16, 2017): 197–205. https://doi.org/10.1080/08958378.2017.1336585.