Variations in coil temperature/power and e‐liquid constituents change size and lung deposition of particles emitted by an electronic cigarette

Introduction:
This text provides an analysis of a study examining the impact of various parameters of electronic cigarettes (e-cigarettes) on particle size and lung deposition. The study uses a single brand of e-cigarette and assesses the effects of power, temperature, PG/Gly ratios, flavors, and nicotine content on particle size and lung deposition.

Key Points:

* The study found that all modifiable aspects of e-cigarette settings or e-liquid constituents directly affect particle size and lung deposition.
* Increasing puff duration and coil power can increase the generation of hazardous components in e-cigarette vapors.
* addition of nicotine and flavorings also increases the number of potential irritants inhaled.
* Particle aerodynamic diameter is the main predictor of where inhaled particles will deposit into the lungs and in what proportion.
* The study assessed the impact of power, temperature, PG/Gly ratios, flavors, and nicotine content on the size of particles emitted by an e-cigarette.
* The inExpose e-cigarette extension was used to standardize the vaping conditions for research purposes.
* Particle size distribution was measured using a Condensation Particle Counter and a Scanning Mobility Particle Sizer spectrometer.
* Lung deposition was predicted using the International Commission on Radiological Protection model.

Main Message:
The study highlights the importance of understanding how e-cigarette settings and e-liquid constituents specifically impact particle size and lung deposition. The results suggest that variations in aerosolization conditions can impact particle size and ultimately lung deposition, which has implications for the health effects of e-cigarette use. Regulators should consider these findings when developing regulations for e-cigarettes.

Lechasseur, ariane, Simon altmejd, Natalie Turgeon, Giorgio Buonanno, Lidia Morawska, David Brunet, Caroline Duchaine, and Mathieu C. Morissette. “Variations in Coil Temperature/Power and E‐liquid Constituents Change Size and Lung Deposition of Particles Emitted by an Electronic Cigarette.” Physiological Reports 7, no. 10 (May 2019): e14093. https://doi.org/10.14814/phy2.14093.