Vapors Produced by Electronic Cigarettes and E-Juices with Flavorings Induce Toxicity, Oxidative Stress, and Inflammatory Response in Lung Epithelial Cells and in Mouse Lung
Introduction:
This text discusses a study on the effects of electronic nicotine delivery systems (ENDS) and electronic cigarettes (e-cigs) on animal cells and tissues, specifically focusing on the lungs. The study aims to provide information necessary to inform the FDa and clinicians about the potential health risks of using ENDS/e-cigs.
Key Points:
* The study found that certain flavored e-liquids exhibit differential in vitro cytotoxicity, suggesting potential toxicities associated with flavor additives.
* Toxic chemicals, including carcinogens, may be released or generated from ENDS/e-cigs, emanating from heated structural materials or forming during the vaporization process.
* Specific particulates, heavy metals, and toxic carbonyls have been measured in ENDS/e-cig aerosols.
* Despite limited evidence that ENDS/e-cigs pose a danger, there is debate about whether meaningful comparisons exist between the health risks of those exposed to tobacco smoke and those exposed to aerosols generated by ENDS devices.
* The presence or generation of OX/ROS associated with ENDS devices and e-liquids has yet to be evaluated and may pose a health risk that is underappreciated.
* The study found that ENDS/e-cigarettes induce oxidative toxicity and inflammatory response by generation of ROS and alteration in redox GSh levels in lung cells in vitro and in vivo in mouse lung exposed to their aerosols, respectively.
Main Message:
The study suggests that exposure to e-cig aerosols/juices incurs measurable oxidative and inflammatory responses in lung cells and tissues that could lead to unrealized health consequences. The findings emphasize the need for further research to fully understand the potential health risks associated with ENDS/e-cigarette use.
Citation
Lerner, Chad a., Isaac K. Sundar, hongwei Yao, Janice Gerloff, Deborah J. Ossip, Scott McIntosh, Risa Robinson, and Irfan Rahman. “Vapors Produced by Electronic Cigarettes and E-Juices with Flavorings Induce Toxicity, Oxidative Stress, and Inflammatory Response in Lung Epithelial Cells and in Mouse Lung.” Edited by M. Firoze Khan. PLOS ONE 10, no. 2 (February 6, 2015): e0116732. https://doi.org/10.1371/journal.pone.0116732.
Lerner, Chad a., Isaac K. Sundar, hongwei Yao, Janice Gerloff, Deborah J. Ossip, Scott McIntosh, Risa Robinson, and Irfan Rahman. “Vapors Produced by Electronic Cigarettes and E-Juices with Flavorings Induce Toxicity, Oxidative Stress, and Inflammatory Response in Lung Epithelial Cells and in Mouse Lung.” Edited by M. Firoze Khan. PLOS ONE 10, no. 2 (February 6, 2015): e0116732. https://doi.org/10.1371/journal.pone.0116732.
