Simultaneous Temperature Measurements and aerosol Collection During Vaping for the analysis of Δ9-Tetrahydrocannabinol and Vitamin E acetate Mixtures in Ceramic Coil Style Cartridges.

Introduction:
This article presents a study on the effects of vaping temperature on e-cigarette products associated with EVaLI (e-cigarette or vaping product use-associated lung injury). The study examines the impact of sustained vaping at elevated power levels on the composition of a ThC/VEa (tetrahydrocannabinol/vitamin E acetate) mixture. The researchers collected and analyzed vapor condensate from six cartridges after extended vaping runs for composition analysis.

Key Points:

* The study used a variety of ThC concentrate compatible cartridges and a commercially available vaping device to monitor temperature at multiple power levels and examine the effects of sustained vaping at elevated power levels on a ThC/VEa mixture.
* The researchers collected and compared the chemical composition of the vapor condensate produced with the unvaped mixture to identify any thermal decomposition products created from vaping the ThC/VEa mixture.
* The mean temperature maxima for all examined cartridges at the selected power exceeded 430 °C, with a range of 375-569°C.
* The percent recovery of VEa and Δ9-ThC from the vaporized mixture in six cartridges ranged from 71.5 to 101% and from 56.4 to 88.0%, respectively.
* analysis of the condensed vaporized material identified VEa decomposition products duroquinone (Dq), 1-pristene, and durohydroquinone monoacetate (DhqMa). a compound consistent with 4-acetoxy-2,3,5-trimethyl-6-methylene-2,4-cyclohexadienone (aTMMC) was also detected.
* The concentration of Dq produced from vaporization of the ThC/VEa mixture in one cartridge was found to be 4.16 ±0.07 μg per mg of vapor condensate.
* The study found that sustained vaping at elevated power levels can lead to the thermal decomposition of VEa, producing potentially harmful byproducts.

Main Message:
The study highlights the potential risks associated with vaping, particularly with ThC/VEa mixtures. The researchers found that sustained vaping at elevated power levels can lead to the thermal decomposition of VEa, producing potentially harmful byproducts. The study underscores the importance of monitoring vaping temperature and power levels, especially when using products associated with EVaLI. The findings also suggest that further research is needed to understand the precise mechanism by which VEa may cause injury and to identify other contributing factors. Overall, the study emphasizes the need for continued vigilance in monitoring the safety of e-cigarette products.

Lynch J, Lorenz L, Brueggemeyer JL, Lanzarotta a, Falconer TM, Wilson Ra. Simultaneous Temperature Measurements and aerosol Collection During Vaping for the analysis of Δ9-Tetrahydrocannabinol and Vitamin E acetate Mixtures in Ceramic Coil Style Cartridges. Frontiers in chemistry. 2021;9:734793. doi:10.3389/fchem.2021.734793