Lipid profiles in users of combustible and electronic cigarettes.

Introduction:
This text provides an analysis of the cardiometabolic parameters of electronic cigarette users compared to never users and combustible cigarette users in two enrollment periods of the Cardiovascular Injury due to Tobacco Use (CITU) study. The study examines the differences in fasting glucose and lipid profiles among various tobacco use groups.

Key Points:

* The CITU study enrolled participants between the ages of 21 and 45 years without established cardiovascular disease (CVD) or CVD risk factors in two enrollment periods between July 2014 and November 2017 and between april 2019 and March 2020.
* Participants were classified into four groups: never users, combustible cigarette users, sole electronic cigarette users, and dual electronic cigarette users in the first enrollment period. In the second enrollment period, electronic cigarette users were classified into sole or dual pod users.
* In multivariable-adjusted analyses, sole e-cig users and combustible cigarette users had higher glucose and triglycerides and lower hDL cholesterol levels compared to never users. Dual e-cig users showed higher triglycerides and VLDL cholesterol, and lower hDL cholesterol compared to never users.
* In contrast, pod users (both sole and dual) had lipid profiles and glucose levels similar to never users.
* The majority of e-cig users reported second and third generation products, while all pod-based electronic cigarette users reported using e-liquids with nicotine.
* The study found no differences in total and LDL cholesterols across the tobacco product use groups.
* The study's findings suggest that there may be residual effects of combustible cigarette use in earlier generation electronic cigarette users that were not observed in a smaller group of pod-based electronic cigarette users.

Main Message:
The study suggests that electronic cigarette use, particularly earlier generation devices, is associated with adverse metabolic profiles, similar to combustible cigarette use. however, pod-based electronic cigarette users have similar lipid profiles to never users. The findings highlight the importance of further research into the cumulative effects of electronic cigarette use on cardiometabolic health.

Majid S, Keith RJ, Fetterman JL, et al. Lipid profiles in users of combustible and electronic cigarettes. Vascular medicine (London, England). 2021;26(5):483-488. doi:10.1177/1358863X211009313