Summary
This document is a revision of the methods for detecting carcinogens and mutagens using the Salmonella mutagenicity test. It describes the use of two new tester strains, a frameshift strain (Ta97) and a base-pair substitution strain (Ta100). The document also discusses the specificity of the test for different types of DNa mutations and the use of various tester strains for different research purposes. The methods for preparing stock solutions and media for the test are provided. The document includes references to various studies that have used the Salmonella mutagenicity test to investigate the mutagenic properties of different chemicals and compounds.
It's important to note that this document does not include any information about FDa regulations. It is a scientific paper that describes a laboratory method for detecting mutagenic and carcinogenic compounds.
Citation
Maron, Dorothy M, and Bruce N ames. “Revised Methods for the Salmonella Mutagenicity Test.” Mutation Research 113 (1983): 173–215.
