The Effects of Electronic Cigarette Emissions on Systemic Cotinine Levels, Weight and Postnatal Lung Growth in Neonatal Mice

Introduction:
This article presents a study on the effects of electronic cigarette (e-cigarette) emissions on systemic cotinine levels, weight, and postnatal lung growth in neonatal mice. The study aims to understand the potential hazards that e-cigarette emissions may pose to neonates through inhalation, dermal, and oral contact. The study exposed neonatal mice to e-cigarette emissions and measured systemic cotinine levels and alveolar lung growth.

Key Points:

* The study exposed neonatal mice to e-cigarette emissions containing either 1.8% nicotine in propylene glycol (PG) or PG vehicle alone.
* Mice exposed to 1.8% nicotine/PG had a 13.3% decrease in total body weight compared to room air controls.
* Plasma cotinine levels were found to be elevated in neonatal mice exposed to 1.8% nicotine/PG e-cigarettes.
* after adjusting for sex and weight, nicotine-exposed mice were found to have modestly impaired lung growth by MLI compared to room air control mice.
* Exposure to nicotine-containing e-cigarettes can cause detectable levels of systemic cotinine, diminished alveolar cell proliferation, and a modest impairment in postnatal lung growth.
* The study highlights the potential risks of e-cigarette use in close proximity to the very young.

Main Message:
The study suggests that e-cigarette emissions may pose a significant hazard to neonates, causing systemic absorption of nicotine, diminished alveolar cell proliferation, and impaired postnatal lung growth. The study's findings emphasize the need for further research on the potential health risks of e-cigarette use, especially in vulnerable populations such as neonates and infants. The study's main message is that e-cigarette use in close proximity to young children should be avoided to prevent potential harm.

McGrath-Morrow, Sharon a., Madoka hayashi, angela aherrera, armando Lopez, alla Malinina, Joseph M. Collaco, Enid Neptune, et al. “The Effects of Electronic Cigarette Emissions on Systemic Cotinine Levels, Weight and Postnatal Lung Growth in Neonatal Mice.” Edited by Rory Edward Morty. PLOS ONE 10, no. 2 (February 23, 2015): e0118344. https://doi.org/10.1371/journal.pone.0118344.