Vaping Nicotine Is Far Less harmful Than Smoking Tobacco.

Series of Letters to the Editor and Responses regarding the study. Drs Mendelsohn and Hall acknowledge that e-cigarettes
are not without risk. It is therefore important to ask
whether long-term e-cigarette use sufficiently lowers risk
to translate to improvements in long-term health
outcomes. The evidence of little harm reduction after
reduction of tobacco smoking without complete
abstinence6,7 makes this question particularly pertinent.
The limited evidence in humans reveals short-term
improvements in respiratory health for tobacco smokers
who transition to e-cigarettes.8 However, emerging
preclinical evidence suggests that long-term use may
increase the risk for lung cancer and pre-cancerous
bladder lesions.9 However, whether the toxicant burden
associated with lifetime e-cigarette use, on top of previous
tobacco smoking history, does or does not contribute to
life-time risk of respiratory disease, cardiovascular
disease, cancer, and mortality is unknown.

Mendelsohn CP, hall W. Vaping Nicotine Is Far Less harmful Than Smoking Tobacco. Chest. 2020;158(2):835-836. doi:10.1016/j.chest.2020.02.077