Platelet reactivity is higher in e-cigarette vaping as compared to traditional smoking.

Introduction:
This text provides information about a study investigating the impact of e-cigarette vaping on platelet reactivity compared to traditional smoking and non-smoking. The study used Multiplate Impedance aggregometry to measure platelet function and inverse probability of treatment weighting (IPTW) to balance participants' characteristics.

Key Points:

* The study included 212 healthy individuals: 37 non-smokers, 102 vapers, and 73 smoked tobacco cigarettes.
* Collagen-induced platelet aggregation was higher in vapers compared to non-smokers and smokers.
* aDP-induced aggregation in vapers was higher compared to non-smokers and numerically increased compared to smokers.
* after adjustment for nicotine amount, platelet aggregation remained higher in vapers than smokers.
* The study found that chronic vaping was associated with higher platelet reactivity as compared to traditional smoking and non-smoking.
* The study controlled for age, gender, body height, body weight, and nicotine amount.
* The study used two stimulants, collagen and aDP, to measure platelet aggregation.

Main Message:
The main message of this study is that chronic vaping is associated with enhanced platelet reactivity, even more than traditional smoking. This finding suggests that the health effects of vaping might be more severe than previously assumed. Further studies are needed to evaluate whether this effect translates to clinical outcomes with a higher incidence of major cardiovascular events. The study highlights the importance of considering the potential cardiovascular risks of e-cigarette use.

Metzen D, M’Pembele R, Zako S, et al. Platelet reactivity is higher in e-cigarette vaping as compared to traditional smoking. International journal of cardiology. 2021;343:146-148. doi:10.1016/j.ijcard.2021.09.005