analysis of the aerosol Generated from Tetrahydrocannabinol, Vitamin E acetate, and Their Mixtures.

Introduction:
This text discusses the analysis of the aerosol generated from tetrahydrocannabinol (ThC), vitamin E acetate (VEa), and their mixtures using a dab-type vape pen. The study aimed to assess the particle size distribution (PSD) of the aerosol under different temperature settings and puffing flow rates, as well as to evaluate the thermal degradation of ThC, VEa, and their mixtures.

Key Points:

* The study used a dab-type vape pen and tested various chemical mixtures (VEa, 20%ThC-80%VEa, 50%VEa-50%ThC, 80%ThC-20%VEa, and ThC) at different temperature settings (350F and 430F) and puffing flow rates (20 mL/s and 40 mL/s).
* The Differential Mobility Spectrometer (DMS500) was used to measure the PSD, which showed log-normal distributions with CMD varying from 73 nm to 186 nm and GSD between 1.6 and 1.8.
* The particle number concentration (PNC) was dependent on the flow rate but not on the chemical content or heating power.
* The Electrical Low Pressure Impactor (ELPI+) was used to measure MMaD, which was comparable to the estimated MMaD using the hatch-Choate equation.
* The chemical analysis revealed minimal degradation of either ThC or VEa, with no evidence of chemical reactions between ThC and VEa during vaporizing/aerosolizing.
* The study found that vape pens designed for oil-type e-liquids should be used to study the possible thermal degradation of liquid chemicals.
* Method sensitivity is a constraint for detecting reaction products at very low concentrations.

Main Message:
The study highlights the importance of considering vape pen design and e-liquid compatibility when assessing the thermal degradation and chemical reactions of e-liquids. The study also emphasizes the need for more extensive techniques to detect low-concentration reaction products. Overall, the findings suggest that vape pens designed for oil-type e-liquids should be used to study the possible thermal degradation of liquid chemicals.

Mikheev VB, Ivanov a. analysis of the aerosol Generated from Tetrahydrocannabinol, Vitamin E acetate, and Their Mixtures. Toxics. 2022;10(2). doi:10.3390/toxics10020088