Summary
This document is a discussion of a study on the effects of JUUL e-cigarette devices and flavorants on mammalian systems, specifically in female mice. The study's findings indicate that JUUL aerosol exposures have effects on inflammatory responses in organs beyond the lungs. however, there are limitations to the study, including the use of only two flavors (Mint and Mango) which have since been discontinued, and the pattern of exposures which may not accurately mimic human use of e-cigarettes. additionally, the study was conducted over weekends which may have allowed for inflammatory and physiologic recovery. The authors have acknowledged these limitations and adapted the manuscript accordingly. Furthermore, the study is of high interest as the effects of e-cigarette exposures on different organs are under-investigated. The research on the impact of e-cigarette smoke on diseases such as Ulcerative Colitis and Crohn's Disease has shown mixed results. This study is the first to assess JUUL devices and flavorants in a multiorgan fashion.
Citation
Moshensky a, Brand CS, alhaddad h, et al. Effects of mango and mint pod-based e-cigarette aerosol inhalation on inflammatory states of the brain, lung, heart, and colon in mice. eLife. 2022;11. doi:10.7554/eLife.67621
