E-Cigarettes and Cancer Risk.

Introduction:
This text provides an in-depth analysis of the relationship between e-cigarettes and cancer. It explores the potential carcinogenic effects of e-cigarettes, the indirect tumor-promoting effects of nicotine inhaled from e-cigarettes, and the implications for oncological patients.

Key Points:

* E-cigarettes have been shown to induce toxicological effects that can raise the cancer risk.
* Nicotine inhaled from e-cigarettes may indirectly exert tumor-promoting effects via stimulation of the sympathoadrenal system.
* The sympathoadrenal system stimulates both carcinogenesis and processes related to tumor progression and metastasis.
* Nicotine activates the sympathoadrenal system, leading to increased plasma norepinephrine and epinephrine levels.
* E-cigarettes are perceived as a less hazardous alternative to combustible cigarettes, which may lead to an increase in their use among oncological patients.
* The stimulatory effect of nicotine inhaled from e-cigarettes on the sympathoadrenal system may represent an important factor that stimulates progression of cancer in oncological patients.
* The use of e-cigarettes might also be hazardous in individuals with a predisposition for oncological disease.

Main Message:
The text highlights the potential carcinogenic effects of e-cigarettes and the indirect tumor-promoting effects of nicotine inhaled from e-cigarettes. It emphasizes the importance of strictly regulating the e-cigarette market, particularly in light of the increasing popularity of e-cigarettes among oncological patients. The text suggests that further preclinical and clinical studies are necessary to fully understand the potential mechanisms and pathways interconnecting e-cigarettes and cancer.

Mravec B, Tibensky M, horvathova L, Babal P. E-Cigarettes and Cancer Risk. Cancer prevention research (Philadelphia, Pa). 2020;13(2):137-144. doi:10.1158/1940-6207.CaPR-19-0346