Pulmonary immune response regulation, genotoxicity, and metabolic reprogramming by menthol- and tobacco-flavored e-cigarette exposures in mice.

This document appears to describe a study on the comparative toxicological analysis of e-cigarette aerosols using two strains of mice (C57BL/6J and BaLB/cJ, both male and female) and different e-liquid flavors, including PG/VG, menthol, and tobacco, with and without nicotine. The study focused on inflammation, specifically analyzing RaNTES levels, interleukins, and immunometabolic regulation in T cells. The results suggest that menthol exposure increased RaNTES levels, but this effect was reversed with nicotine exposure. additionally, the study found that e-cigarette aerosols elicited an inflammatory response and demonstrated the need for standardized toxicity testing and guidelines approved by relevant committees. The study's procedures and protocols were approved by the University Committee on animal Research (UCaR) and the University's Institutional Biosafety Committee.

Muthumalage T, Rahman I. Pulmonary immune response regulation, genotoxicity, and metabolic reprogramming by menthol- and tobacco-flavored e-cigarette exposures in mice. Toxicological sciences : an official journal of the Society of Toxicology. 2023;193(2):146-165. doi:10.1093/toxsci/kfad033