Summary
Introduction:
This article discusses a study on the identification and quantification of aroma compounds in e-cigarette products and their toxicity evaluation in hUVEC/Tert2 cells. The study aimed to identify possible undesirable aroma compounds in e-liquids and e-concentrates and test their toxicity on human cells.
Key Points:
* The study identified and quantified several aroma compounds, including benzaldehyde, cinnamaldehyde, and estragole, in 34 e-concentrates and 21 e-liquids using gas chromatography-mass spectrometry (GC-MS).
* The researchers found that some e-concentrates contained highly concentrated flavoring compounds and limonene oxide, a potential contact allergen.
* The researchers tested the toxicity of single-aroma standards and e-liquid samples on hUVEC/Tert2 cells, which are commonly used to evaluate the toxicity of chemicals.
* The results showed that some single-flavoring chemicals, such as cinnamic aldehyde, revealed significant toxic effects on hUVEC/Tert2 cells.
* The researchers also observed that the treatment with the pure e-liquid base reduced metabolic activity by approximately 18%.
* The study suggests that the process of EU-wide regulation of e-cigarettes and their aroma compounds is still ongoing, and potential risks may arise when exposed to a high concentration of flavoring chemicals.
* The study highlights the need for further investigation into the toxicity and regulation of aroma compounds in e-cigarettes.
Main Message:
The study provides valuable insights into the composition and concentration of aroma compounds in e-cigarette products and their toxicity to human cells. The findings suggest that some single-flavoring chemicals, such as cinnamic aldehyde, may pose potential health risks and should be regulated accordingly. The study also emphasizes the need for further research to ensure the safety and regulation of e-cigarettes and their aroma compounds.
Citation
Noël JC, Rainer D, Gstir R, Rainer M, Bonn G. quantification of selected aroma compounds in e-cigarette products and toxicity evaluation in hUVEC/Tert2 cells. Biomedical chromatography : BMC. 2020;34(3):1. doi:10.1002/bmc.4761
