E-cigarette aerosol impairs male mouse skeletal muscle force development and prevents recovery from injury.

Introduction:
This text provides an in-depth analysis of a research article examining the effects of e-cigarette aerosol on mouse skeletal muscle function. The study found that e-cigarette aerosol impairs muscle force development and prevents recovery from injury in male mice. The research also looked at the impact of the vehicle used to deliver nicotine in these vaping devices, polyethylene glycol (PG) and vegetable glycerin (VG), on muscle function.

Key Points:

* The study found that nicotine-containing e-cigarette aerosol reduces the maximal force produced by the extensor digitorum longus (EDL) by 30%-40% and decreases running speed by 8%.
* The study found that nicotine aerosol exposure increases adrenal and plasma epinephrine and norepinephrine levels, leading to increased muscle and liver glycogen stores.
* In nicotine aerosol-exposed mice, muscle regenerating from injury only recovers force to 80% of noninjured levels.
* The structure of neuromuscular junctions (NMJs) is not affected by e-cigarette aerosols.
* Both nicotine and PG/VG reduce running speed and impair muscle function recovery in injured muscle.
* Cardiac left ventricular systolic function is preserved, but left ventricular myocardial relaxation is altered in both types of aerosol exposures.

Main Message:
The study suggests that e-cigarette use may have a negative impact on muscle force and regeneration due to compromised glucose metabolism and contractile function in male mice. The results highlight the importance of further research into the potential long-term health effects of e-cigarette use, particularly in young people who may be more susceptible to these effects. The use of e-cigarettes has become increasingly popular in recent years, and it is essential to understand the potential risks associated with their use to inform public health policy and regulations. as an expert in regulatory matters, it is crucial to consider the findings of this study when developing policies and regulations around e-cigarette use.

Nogueira L, Zemljic-harpf aE, Yusufi R, et al. E-cigarette aerosol impairs male mouse skeletal muscle force development and prevents recovery from injury. american journal of physiology Regulatory, integrative and comparative physiology. 2022;323(6):R849-R860. doi:10.1152/ajpregu.00314.2021