Summary
xBased on the information provided, the expert panel has drawn conclusions regarding the reproductive and developmental hazards of propylene glycol (PG). Studies in multiple laboratory animal species have indicated that high oral doses of PG did not produce any adverse developmental or reproductive effects. however, these conclusions are subject to change as new information on toxicity and exposure becomes available.
The MacKee study, which has limited utility in drawing conclusions regarding PG penetration across healthy human skin, was evaluated along with a rat dermal penetration in vitro study. These studies showed no uptake of PG, suggesting minimal concern for adverse effects related to dermal exposure.
The NTP has presented conclusions regarding the possibilities that human development or reproduction might be adversely affected by exposure to PG, with the current level of concern being minimal. however, there is insufficient hazard and/or exposure data to make a definitive assessment in some cases.
In summary, based on the studies reviewed, the expert panel has found minimal concern for reproductive and developmental hazards associated with PG exposure, but the conclusions may change as new information emerges.
Citation
"NTP-CERhR Monograph on the Potential human Reproductive and Developmental Effects of Propylene Glycol" NIh Publication No. 04-4482 (2004).
