Summary
Introduction:
This text analyzes the particle size distribution of aerosols from electronic nicotine delivery system (ENDS) products, which is an important factor in predicting the dose of inhaled material in dosimetry models. The study aims to determine the particle size distribution of 20 different cartridge-based ENDS products using a low-flow cascade impactor and assess losses and vapor phase amount. The levels of nicotine, glycerin, propylene glycol, water, and menthol in the formulations of each product were also measured.
Key Points:
* a low-flow cascade impactor was used to determine the particle size distribution (MMaD and GSD) of 20 different cartridge-based ENDS products.
* The collection efficiency of the system was measured to assess losses and vapor phase amount.
* The levels of nicotine, glycerin, propylene glycol, water, and menthol in the formulations of each product were also measured.
* Regardless of the ENDS product formulation, the MMaD of all tested products was similar and ranged from 0.9 to 1.2 μm with a GSD ranging from 1.7 to 2.2.
* There was no consistent pattern of change in the MMaD and GSD as a function of number of puffs (cartridge life).
* The collection efficiency indicated that 9% –26% of the generated mass was deposited in the collection system or was in the vapor phase.
* The particle size distribution data are suitable for use in aerosol dosimetry programs.
Main Message:
The study found that the particle size distribution of aerosols from cartridge-based ENDS products is similar regardless of their formulations, making it suitable for use in aerosol dosimetry programs. This information is crucial in understanding the potential health impacts of ENDS products and can aid in the development of appropriate regulations for these products. as an expert in regulatory matters, understanding such scientific studies is essential to ensure that regulations are based on sound scientific evidence.
Citation
Oldham, Michael J., Jingjie Zhang, Mark J. Rusyniak, David B. Kane, and William P. Gardner. “Particle Size Distribution of Selected Electronic Nicotine Delivery System Products.” Food and Chemical Toxicology 113 (March 2018): 236–40. https://doi.org/10.1016/j.fct.2018.01.045.
