Real-World Evidence of Differences in Biomarkers of Exposure to Select harmful and Potentially harmful Constituents and Biomarkers of Potential harm Between adult E-Vapor Users and adult Cigarette Smokers.

Introduction:
This article presents a cross-sectional study comparing biomarkers of exposure (BOE) to tobacco smoke constituents and biomarkers of potential harm (BOPh) in adult former cigarette smokers who have switched to exclusive use of e-vapor products (EVPs) and current smokers of conventional cigarettes. The study aims to provide real-world evidence of differences in BOE and BOPh following a long-term product switch from conventional cigarettes to EVPs.

Key Points:

* The study enrolled 217 participants, of which 194 were included in the biomarker analysis set.
* Participants were divided into two groups: exclusive adult EVP users (aEVP) and exclusive adult cigarette smokers (aS).
* aEVP had statistically significantly lower levels of BOE to specific hPhCs compared with aS, including 86% for total NNaL, 36% for urinary nicotine equivalents, 46% for 3-hPMa, and 47% for COhb.
* aEVP had statistically significantly lower levels of BOPh compared with aS, including 9% for WBC count, 29% for 11-dehydrothromboxane B2, 23% for 8-epi-prostaglandin F2 α, and 16% for sICaM-1.
* The study demonstrates the feasibility of a new approach for collecting real-world evidence.
* The study suggests that exclusive EVP use may present lower health risks compared with smoking cigarettes.

Main Message:
This study provides real-world evidence of differences in BOE and BOPh following a long-term product switch from conventional cigarettes to EVPs. The results suggest that exclusive EVP use may present lower health risks compared with smoking cigarettes, providing valuable information for regulatory matters related to EVPs. The study's findings add to the growing body of evidence regarding the potential health effects of EVPs relative to cigarette smoking.

Oliveri D, Liang q, Sarkar M. Real-World Evidence of Differences in Biomarkers of Exposure to Select harmful and Potentially harmful Constituents and Biomarkers of Potential harm Between adult E-Vapor Users and adult Cigarette Smokers. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2020;22(7):1114-1122. doi:10.1093/ntr/ntz185