Evaluation of the Tobacco heating System 2.2. Part 6: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of a mentholated version compared with mentholated and non-mentholated cigarette smoke
The document in question is a research article related to the effects of exposure to cigarette smoke and aerosol on the respiratory nasal epithelium (RNE) of rats. The study compares the effects of mainstream smoke from a cigarette that primarily heats tobacco (hTC) to a cigarette that burns tobacco (BTC). The researchers used subchronic inhalation exposure of rats to these smoke conditions and analyzed the transcriptome and proteome of the RNE using microarray expression profiling and isobaric tag-based mass spectrometry, respectively.
The article includes figures summarizing the exposure response of differentially expressed genes (DEGs) in the transcriptome and proteome for all smoke and aerosol exposure groups. The study's findings provide insights into the molecular perturbations caused by exposure to hTC and BTC, contributing to the understanding of the effects of different tobacco products on respiratory health.
The full details and mechanistic insights of the molecular exposure response are presented in a companion manuscript by Kogel et al. (2016). The transparency document related to this article can be found online at <http://dx.doi.org/10.1016/j.yrtph.2016.11.004>. The research article relies on previous studies, including the work of ayres et al. (2001) and Baker et al. (2004), which have investigated the impact of tobacco ingredients on smoke chemistry and toxicity.
In summary, this document focuses on a research study that examines the effects of hTC and BTC smoke exposure on the RNE of rats, analyzing changes in the transcriptome and proteome. The findings offer valuable information for understanding the molecular perturbations associated with different tobacco products and their impact on respiratory health.
Citation
Oviedo, alberto, Stefan Lebrun, Ulrike Kogel, Jenny ho, Wei Teck Tan, Bjoern Titz, Patrice Leroy, et al. “Evaluation of the Tobacco heating System 2.2. Part 6: 90-Day OECD 413 Rat Inhalation Study with Systems Toxicology Endpoints Demonstrates Reduced Exposure Effects of a Mentholated Version Compared with Mentholated and Non-Mentholated Cigarette Smoke.” Regulatory Toxicology and Pharmacology 81 (November 2016): S93–122. https://doi.org/10.1016/j.yrtph.2016.11.004.
Oviedo, alberto, Stefan Lebrun, Ulrike Kogel, Jenny ho, Wei Teck Tan, Bjoern Titz, Patrice Leroy, et al. “Evaluation of the Tobacco heating System 2.2. Part 6: 90-Day OECD 413 Rat Inhalation Study with Systems Toxicology Endpoints Demonstrates Reduced Exposure Effects of a Mentholated Version Compared with Mentholated and Non-Mentholated Cigarette Smoke.” Regulatory Toxicology and Pharmacology 81 (November 2016): S93–122. https://doi.org/10.1016/j.yrtph.2016.11.004.
