New analytical Method for quantifying Flavoring Chemicals of Potential Respiratory health Risk Concerns in e-Cigarette Liquids.

Introduction:
This text discusses a new analytical method for quantifying flavoring chemicals of potential respiratory health risk concerns in e-cigarette liquids. The method measures the concentrations of 20 flavoring chemicals using an accurate and precise method, which is crucial for estimating the potential health risk of inhaling these chemicals. The study also evaluates over 200 commercially available e-cigarette liquids using this method and reports the concentrations of the flavoring chemicals found in these products.

Key Points:

* The study developed an analytical method to measure the concentrations of 20 flavoring chemicals in e-cigarette liquids.
* The method is accurate and precise, with a wide dynamic working range and a rapid routine analysis of flavoring additives.
* The method was validated and used to evaluate over 200 commercially available e-cigarette liquids.
* The concentrations of pulegone, a suspected carcinogen, varied from below the limit of quantitation (BLOq) to 0.32 mg/ml.
* acetoin and vanillin, known precursors to more cytotoxic byproducts, ranged from BLOq to 1.52 mg/ml and from BLOq to 16.22 mg/ml, respectively.
* The study identified several unknown peaks in the e-cigarette liquids, which may be benzaldehyde dimethyl acetal, isopulegone, 2'-hydroxybutyrophenone, cinnamaldehyde dimethyl acetal, and 4-(2-hydroxyethyl)-2,6-dimethoxyphenol.
* Carryover was observed for butanoic acid, ethyl maltol, ethyl vanillin, isovanillin, maltol, and vanillin when PG:VG blanks were analyzed following concentrated samples.
* The method can be applied to assess inhalation exposure to flavoring chemicals in e-cigarette users.

Main Message:
The new analytical method developed in this study is accurate and precise in measuring the concentrations of 20 flavoring chemicals in e-cigarette liquids. The study also highlights the importance of quantifying these chemicals in e-cigarette liquids, given the potential health risks associated with inhaling them. The results demonstrate that some flavoring chemicals, such as pulegone, are present in e-cigarette liquids at concentrations that may pose a health risk. Therefore, it is crucial to regulate and monitor the use of these chemicals in e-cigarette products to protect public health. Overall, the study emphasizes the need for further research and regulatory actions to ensure the safety of e-cigarette users.

Page MK, Goniewicz ML. New analytical Method for quantifying Flavoring Chemicals of Potential Respiratory health Risk Concerns in e-Cigarette Liquids. Frontiers in chemistry. 2021;9:763940. doi:10.3389/fchem.2021.763940