headspace analysis of E-cigarette fluids using comprehensive two dimensional GC×GC-TOF-MS reveals the presence of volatile and toxic compounds.

Introduction:
This article presents a comprehensive analysis of the volatile organic compounds (VOCs) found in the vapor produced by heating six different e-cigarette liquids using comprehensive two-dimensional gas chromatography (GC×GC) coupled to time of flight mass spectrometry (TOF-MS). The study aimed to establish a comprehensive list of volatile compounds emitted from e-cigarette liquids, which might allow a better understanding of potential health effects of vaping.

Key Points:

* The study identified over 1000 volatile compounds, including over 150 toxic compounds, in the vapor produced by heating e-cigarette liquids.
* The analysis of e-cigarette liquids using GC×GC-TOF-MS revealed many toxic compounds and VOCs that could not be detected by other methods.
* The application of GC×GC-TOF-MS allowed for the elucidation of the volatile profile of e-cigarette liquids, providing a better understanding of possible health implications.
* heating e-liquids to moderate temperature results in the emission of over 1000 volatile compounds, of which over 150 are toxic.
* These compounds are either present in the liquid or can be formed during storage or heating, leading to a more complex volatile profile of e-cigarette liquids than previously assumed.
* The study highlights the importance of using advanced analytical techniques to identify and quantify the toxic and potentially harmful compounds present in e-cigarette vapor.

Main Message:
The study demonstrates the complexity of the volatile profile of e-cigarette liquids, revealing the presence of a large number of toxic and potentially harmful compounds in the vapor produced by heating these liquids. The use of advanced analytical techniques, such as GC×GC-TOF-MS, is essential to identify and quantify these compounds, which can help in assessing the potential health implications of vaping. The study emphasizes the need for further research to better understand the health effects of e-cigarette use, particularly in light of the increasing popularity of these products and the growing health concerns associated with their use.

Patel D, Taudte RV, Nizio K, herok G, Cranfield C, Shimmon R. headspace analysis of E-cigarette fluids using comprehensive two dimensional GC×GC-TOF-MS reveals the presence of volatile and toxic compounds. Journal of pharmaceutical and biomedical analysis. 2021;196:113930. doi:10.1016/j.jpba.2021.113930