Summary
The document discusses the role of certain flavorings in e-cigarettes and their potential effects on various pathways and systems in the body. here are the key points:
1. Certain flavorings, such as those that regulate the JNK/aKT pathway, alleviate disruption of the cholinergic and monoaminergic systems, enhance mitochondrial function, and have sedative/anti-convulsant effects.
2. These flavorings are often used in e-cigarettes, including in a 'banana pudding' e-liquid, and are one of three constituents in this product.
3. Research suggests that there is a sex-difference in the use of characterizing flavored products, with women more likely than men to use these products and to value flavor availability.
4. The document also suggests that characterizing flavors might attract specific and potentially vulnerable populations, and that characterizing flavorants might have sex-specific effects.
Overall, the document highlights the potential effects of certain flavorings in e-cigarettes and the importance of considering sex-differences in their use and effects.
Citation
Patten T, De Biasi M. history repeats itself: Role of characterizing flavors on nicotine use and abuse. Neuropharmacology. 2020;177:108162. doi:10.1016/j.neuropharm.2020.108162
