Nicotine dose-dependent epigenomic-wide DNa methylation changes in the mice with long-term electronic cigarette exposure.

The study by Peng et al. (year unspecified) examines the effects of E-cigarette exposure on DNa methylation. The research found that nicotine dose from E-cigarettes caused dose-dependent changes in DNa methylation, particularly in genes associated with nicotine dependence and inflammation. No significant changes were observed in white blood cell composition after 14 weeks of E-cigarette exposure. The study utilizes a novel dye-bias correction method for Illumina Methylation BeadChip, as described in Niu's study (2017), and compared Beta-value and M-value methods for quantifying methylation levels, as discussed in Du's study (2010). The study aims to contribute to understanding the epigenetic mechanisms underlying the health effects of E-cigarette use.

Peng G, Xi Y, Bellini C, et al. Nicotine dose-dependent epigenomic-wide DNa methylation changes in the mice with long-term electronic cigarette exposure. american journal of cancer research. 2022;12(8):3679-3692.