Summary
Introduction:
This text provides an analysis of the investigation comparing the nicotine delivery and user reactions to Juul EU (20 mg/ml) with Juul US (59 mg/ml), cigarettes, and other e-cigarette products. The study aims to determine the pharmacokinetic profile and user ratings of these products.
Key Points:
* The study used a within-subjects crossover design, where 18 vapers used their own brand cigarette, Juul US, and Juul EU for 5 minutes after overnight abstinence.
* Blood samples were taken at baseline and 2, 4, 6, 8, 10, and 30 minutes after initiating product use.
* Juul EU delivered less nicotine than Juul US and own brand cigarettes, with Cmax and aUC0≥30 significantly lower for Juul EU.
* Juul EU was perceived to relieve urges to smoke less than Juul US and to provide less nicotine.
* Juul EU delivered less nicotine than refillable e-cigarettes and cig-a-like e-cigarettes, though the difference was not significant for Tmax.
* Subjective ratings of Juul EU and other e-cigarette products were similar.
* The study suggests that Juul EU may have more limited potential in helping smokers quit due to its lower nicotine delivery.
Main Message:
The main message of this investigation is that Juul EU delivers much less nicotine to users than Juul US, and also less than refillable e-cigarette products. This lower nicotine delivery may limit its potential in helping smokers quit, highlighting questions raised about the rationale of the nicotine content limit for e-cigarettes stipulated in the EU TPD. The study's findings suggest that at least some smokers who could have switched to less dangerous alternatives with comparable nicotine delivery may be unable to access them due to the regulation.
Citation
Phillips-Waller a, Przulj D, Smith KM, Pesola F, hajek P. Nicotine delivery and user reactions to Juul EU (20 mg/ml) compared with Juul US (59 mg/ml), cigarettes and other e-cigarette products. Psychopharmacology. 2021;238(3):825-831. doi:10.1007/s00213-020-05734-2
