Cardiovascular function during early development is suppressed by cinnamon flavored, nicotine-free, electronic cigarette vapor.

Introduction:
This article presents a study examining the effects of nicotine-free, cinnamon and chocolate flavored electronic cigarette vapor on cardiovascular function during early development in zebrafish embryos. The research aims to evaluate potential health effects of vaping on systems other than the respiratory system, specifically focusing on cardiovascular function during early development due to maternal use of electronic cigarettes.

Key Points:

* The study exposed wild-type zebrafish embryos to electronic cigarette vapor produced from a second-generation style vape pen, incorporating the vapor into dechlorinated water at varying concentrations (0.6, 12, and 25 puffs/L).
* Exposures lasted for 24 hours, and cardiovascular videos were recorded and analyzed to measure end systolic volume, end diastolic volume, stroke volume, heart rate, cardiac output, red blood cell density, and arterial and venous blood vessel diameters.
* Results showed that cinnamon flavored electronic cigarette vapor at 25 puffs/L significantly decreased all cardiovascular parameters measured, except blood vessel diameter. No significant effect on any measured parameter was observed at 0.6 or 12 puffs/L with either flavor.
* The study suggests that cinnamon flavored electronic cigarette vapor can affect cardiovascular function during early development, even in the absence of nicotine, particularly at elevated exposure concentrations.

Main Message:
This study highlights the potential health risks associated with the use of electronic cigarettes, specifically with cinnamon flavored vapor. The findings indicate that even nicotine-free vapor can have detrimental effects on cardiovascular function during early development, emphasizing the need for further research on the potential health impacts of electronic cigarette use. as regulatory agencies continue to evaluate the safety and risks of electronic cigarettes, these results underscore the importance of considering the potential effects on various body systems and developmental stages.

Piechowski JM, Bagatto B. Cardiovascular function during early development is suppressed by cinnamon flavored, nicotine-free, electronic cigarette vapor. Birth defects research. 2021;113(16):1215-1223. doi:10.1002/bdr2.1951