Increased sensitivity to D9-ThC-induced rewarding effects after seven-week exposure to electronic and tobacco cigarettes in mice.

The findings suggest that pre-exposure to electronic cigarettes (e-CIGs) or traditional cigarettes (CIGs) can lead to a long-lasting increased sensitivity to the rewarding effects of Δ9-ThC, even after cessation of exposure. This increased sensitivity is observed up to 66 days after exposure cessation. additionally, e-CIG and CIG exposure is associated with greater concentrations of ΔFosB, which determines an individual's vulnerability to the stress of social defeat and susceptibility to chronic stress. These changes in ΔFosB concentrations can lead to increased Glua1 levels in the Nac and increased medium spiny neuron excitability in response to glutamate. Previous research has also shown that exposure to e-CIGs/CIGs affects emotional profile from 24 hours up to 30 days after nicotine withdrawal, and the current study is evaluating whether this alteration persists for 60 days.

Ponzoni L, Moretti M, Braida D, et al. Increased sensitivity to D9-ThC-induced rewarding effects after seven-week exposure to electronic and tobacco cigarettes in mice. Eur Neuropsychopharmacol. 2019;29:566-576. doi:10.1016/j.euroneuro.2019.02.001