Summary
Introduction:
This article examines the impact of electronic cigarette (E-cigarette) exposure on bone marrow hematopoietic stem and progenitor cells (hSPCs) in a murine model. The study investigates the effects of chronic E-cigarette exposure on hSPC number and function, as well as the potential for E-cigarette exposure to enhance the selective advantage of hSPCs carrying myeloproliferative neoplasm (MPN) and clonal hematopoiesis of indeterminate potential (ChIP) associated mutations.
Key Points:
* The study used a murine model of chronic nose-only inhalation exposure to assess the effects of E-cigarette aerosol on bone marrow hSPCs.
* Chronic E-cigarette exposure negatively impacts hSPC number but not hSC function in transplant assays.
* E-cigarette exposure slightly increases JaK2V617F mutant cells in peripheral blood but does not affect TET2−/− cells.
* Two months of E-cigarette exposure followed by an acute inflammatory stimulus does not affect hSC recovery in primary transplants, but mice transplanted with bone marrow from E-cigarette exposed LPS challenged mice demonstrated a marked increase in peripheral blood monocyte counts.
* hSCs subject to an inflammatory challenge from E-cigarette exposed mice showed a persistent effect of the LPS challenge several months post-transplant unlike the air controls.
Main Message:
The study provides novel evidence on the potential harm of vaping associated products on stem and progenitor cells. The findings suggest that chronic E-cigarette exposure can alter bone marrow hematopoiesis and induce an aged hSC phenotype in response to an acute inflammatory stimulus. additionally, the study suggests that E-cigarette exposure may enhance the selective advantage of hSPCs carrying MPN and ChIP associated mutations, although further research is needed to confirm these findings. Overall, the study highlights the potential health risks associated with E-cigarette use and the need for further research to better understand the long-term effects of E-cigarette exposure on the hematopoietic system.
Citation
Ramanathan G, Craver-hoover B, arechavala RJ, et al. E-Cigarette Exposure Decreases Bone Marrow hematopoietic Progenitor Cells. Cancers. 2020;12(8). doi:10.3390/cancers12082292
