Metabolomics-based safety evaluation of acute exposure to electronic cigarettes in mice.

Introduction:
This text discusses a study on the effects of acute exposure to electronic cigarettes (E-cigs) on organism metabolism in mice. The study aimed to contribute to E-cigs policy development by evaluating the adverse effects of E-cigs on organs and changes in metabolomics.

Key Points:

* The study found that acute exposure to E-cigs induced reactive oxygen species (ROS), oxidative damage, and apoptosis in multiple organs.
* amino acids-based Tricarboxylic acid (TCa) cycle is the most key metabolic pathway induced by E-cigs.
* Type 2 diabetes mellitus and lung cancer were associated with metabolites change caused by E-cigs.
* The study used hematoxylin and eosin (h &E) staining, Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) assay, dihydroethidium (DhE) staining, and q Exactive high field (hF) mass spectrometer to conduct metabolomics.
* Trend analysis and pathway enrichment analysis were used to identify the type of compounds that change over time and the affected metabolic pathways.
* Metabolites-diseases network analysis found that the type 2 diabetes mellitus, propionicacidemia, defect in long-chain fatty acids transport and lung cancer may be related to E-cigs exposure.
* The study provides important clues for metabolites biomarkers of E-cigs acute exposure and is beneficial for disease prevention.

Main Message:
The study highlights the adverse effects of acute exposure to E-cigs on organs and changes in metabolomics in mice. The findings provide valuable information for E-cigs policy development and disease prevention. The study suggests that E-cigs could induce oxidative damage, apoptosis, and metabolic disorders, which may be associated with type 2 diabetes mellitus and lung cancer. Therefore, it is crucial to regulate E-cigs use and raise public awareness of their potential health risks.

Ren X, Lin L, Sun q, et al. Metabolomics-based safety evaluation of acute exposure to electronic cigarettes in mice. The Science of the total environment. 2022;839:156392. doi:10.1016/j.scitotenv.2022.156392