Behavior-based yield for electronic cigarette users of different strength eliquids based on natural environment topography.

Introduction:
This article provides an analysis of the impact of nicotine strength on total particulate matter (TPM) and nicotine consumed per puff in electronic cigarette users. The study aims to understand topography as a compensatory mechanism for nicotine intake.

Key Points:

* The study involved 33 experienced vape pen users who were assigned an NJOY VapePen and aVaIL brand Tobacco Row eliquid with their usual nicotine strength (low, medium, or high).
* Participants vaped through a monitor to record every puff during one week, and nicotine and TPM yield per puff were determined based on topography characteristics.
* Group-wise mean flow rate was lower for low nicotine strength users compared to medium strength users (p=0.2), and duration was higher compared to medium strength users (p=0.09).
* Larger TPM was consumed per puff for low nicotine strength users compared to medium strength users (p=0.07), yet nicotine per puff for low nicotine strength users was less than medium strength users (p=0.3).
* high nicotine strength users took smaller volumes than low (p=0.1) or medium (p=0.17) nicotine strength users, and there was little difference between low and medium nicotine strength users (p=0.47).
* The study suggests that topography is a compensatory mechanism, and the use of low nicotine strength eliquids can increase TPM, which can lead to an increase in harmful and potentially harmful constituents (hPhCs).
* Regulatory review of new products should consider natural use topography and realistic use exposures to nicotine, TPM, and hPhCs.

Main Message:
The study highlights the importance of considering topography as a compensatory mechanism in electronic cigarette use. The findings suggest that the use of low nicotine strength eliquids can increase TPM, which can lead to an increase in hPhCs. Therefore, regulatory review of new products should consider natural use topography and realistic use exposures to nicotine, TPM, and hPhCs to ensure public health protection.

Robinson RJ, hensel EC. Behavior-based yield for electronic cigarette users of different strength eliquids based on natural environment topography. Inhalation toxicology. 2019;31(13-14):484-491. doi:10.1080/08958378.2020.1718804