Summary
Introduction:
This text discusses a study that aimed to investigate the relationship between tobacco product use and inflammation in the splenocardiac axis, which includes the amygdala, aorta, bone marrow, and spleen. The study compared nonsmokers, electronic cigarette users, and tobacco smokers using FDG-PET/CT scans to measure metabolic activity in these tissues.
Key Points:
* The study included 45 participants, divided into three groups: nonsmokers, electronic cigarette users, and tobacco smokers.
* Participants underwent FDG-PET/CT scans to measure metabolic activity in the amygdala, aorta, bone marrow, and spleen.
* The study found a moderate to strong correlation between metabolic activity in all target tissues, indicating the existence of the splenocardiac axis.
* There were no significant differences in metabolic activity between the three groups in any target tissue.
* Cotinine levels were similar between electronic cigarette users and tobacco smokers, indicating light use in both groups.
* The study suggests that the splenocardiac axis may play a role in the development of atherosclerosis, and that amygdala activation may act as an instigator for hematopoiesis.
* The study also suggests that the effects of long-term e-cigarette use versus tobacco cigarette smoking in long-time users may be worth exploring.
* The study had some limitations, including a small sample size and the lack of plasma markers of inflammation and oxidative stress.
Main Message:
The study suggests that the splenocardiac axis may play a role in the development of atherosclerosis and that amygdala activation may act as an instigator for hematopoiesis. however, the study did not find significant differences in metabolic activity between nonsmokers, electronic cigarette users, and tobacco smokers in any target tissue. The study emphasizes the need for further research to better understand the relationship between tobacco product use, the splenocardiac axis, and inflammation.
Citation
Ruedisueli I, arastoo S, Gupta PK, Gornbein J, Middlekauff hR. Neural-hematopoietic-inflammatory axis in nonsmokers, electronic cigarette users, and tobacco smokers. Physiological reports. 2022;10(19):1. doi:10.14814/phy2.15412
