Summary
Introduction:
This text provides an in-depth analysis of a study examining the impact of various e-cigarette liquids on an alveolar-capillary barrier model. The study employs a well-characterized in vitro model of the alveolar-capillary barrier and exposes it to different e-liquid vehicles and flavors, with and without nicotine, to assess their effects on barrier integrity, oxidative stress, inflammation, and cell death.
Key Points:
* The study used a well-characterized in vitro model of the alveolar-capillary barrier.
* The model was exposed to different e-liquid vehicles (PG and VG) and flavors, with and without nicotine.
* The vehicles, due to their hypertonic properties, modified the alveolar-capillary barrier integrity by modifying occludin expression.
* Below a 10% concentration, the vehicles did not trigger oxidative stress or cell death.
* Different results were observed between flavored e-liquids: while red fruits and mint-eucalyptus disrupted alveolar-capillary barrier integrity, triggered oxidative stress and cell death, blond tobacco had no worse effect compared to the vehicles.
* The addition of nicotine in the latter e-liquid increased oxidative stress and cell death compared to the vehicles.
* Mint-eucalyptus e-liquid increased some inflammation markers.
Main Message:
The study reveals that e-liquids alter the alveolar-capillary barrier's homeostasis, depending on flavor and nicotine presence. These findings suggest potential risks associated with e-cigarette use, emphasizing the need for further research and regulation to ensure user safety.
Citation
Sabo aN, Filaudeau E, Da Silva S, Becker G, Monassier L, Kemmel V. Flavoured and nicotine-containing e-liquids impair homeostatic properties of an alveolar-capillary cell model. Food and chemical toxicology : an international journal published for the British Industrial Biological Research association. 2023;174:113650. doi:10.1016/j.fct.2023.113650
