Summary
Introduction:
This text provides an in-depth analysis of the stability and degradation of cannabidiol (CBD) in e-liquid formulations. The study compares the stability of plant-based CBD isolate and synthetic CBD in e-liquids stored under various conditions and identifies the substances formed during their storage. The text also discusses the implications of the findings for the regulation and quality control of CBD products.
Key Points:
* The study used UhPLC-TIMS-TOF-MS, coupled with an in-house spectral library based on the detailed analysis of 39 phytocannabinoids, to detect differences in the cannabinoid profiles of CBD-containing liquids and to identify substances that formed during their storage under varying conditions of temperature and light exposure.
* Plant-based CBD isolate in e-liquid formulations was associated with a greater number of impurities compared to synthetic CBD. hU-331 was initially detected in e-liquids containing CBD from both sources, but the plant-based CBD formulation also contained CBDV, CBDP, CBDh, 6α-Oh-CBD, and 7-Oh-CBD. These plant-specific impurities may act as markers to differentiate CBD from different sources.
* CBD in e-liquid remained relatively stable when stored at 4°C in the dark, but multiple degradation products, including CBE and CBE stereoisomer, were formed when the e-liquid was stored at ambient and elevated temperatures.
* The study identified several other impurities that differed between plant-derived and synthetic CBD and which are potentially diagnostic of the CBD source.
* The findings have implications for the regulation and quality control of CBD products, highlighting the need for rigorous testing and quality control measures to ensure the safety and efficacy of CBD products.
Main Message:
The study highlights the importance of understanding the stability and degradation of CBD in e-liquid formulations. The findings underscore the need for rigorous testing and quality control measures to ensure the safety and efficacy of CBD products. The study also demonstrates the potential of UhPLC-TIMS-TOF-MS as a tool for the analysis and quality control of CBD products. Overall, the study provides valuable insights into the stability and degradation of CBD in e-liquid formulations and has important implications for the regulation and quality control of CBD products.
Citation
Schwarzenberg a, Carpenter h, Wright C, Bayazeid O, Brokl M. Characterizing the degradation of cannabidiol in an e-liquid formulation. Scientific reports. 2022;12(1):20058. doi:10.1038/s41598-022-23910-6
