associations of Demographics, Dependence, and Biomarkers With Transitions in Tobacco Product Use in a Cohort of Cigarette Users and Dual Users of Cigarettes and E-cigarettes.

Introduction:
This text presents the results of a study that aimed to understand the factors associated with transitions in tobacco product use among cigarette users and dual users of cigarettes and e-cigarettes. The study followed participants every 2 months for up to 2 years and used a multistate transition model to estimate transition rates between different tobacco product use states.

Key Points:

* The study found that dual users were more likely to quit smoking than cigarette-only users, but the overall impact was small because most dual users returned to cigarette-only use.
* E-cigarette dependence promoted continued dual use rather than smoking cessation.
* high motivation to quit smoking and the sensory, social, and emotional enjoyment of e-cigarettes facilitated smoking cessation in dual users.
* Cigarette dependence and spousal smoking were barriers to cigarette cessation for dual users.
* The study used a cohort of 380 adult daily cigarette users and dual users, and followed them every 2 months for up to 2 years.
* The study estimated transition rates between noncurrent, cigarette-only, e-cigarette-only, and dual use states using a multistate transition model.
* The study estimated univariable hazard ratios for demographics, dependence measures, biomarkers, spousal or partner behaviors, and other measures.

Main Message:
The study highlights the importance of understanding the barriers and facilitators of tobacco product use transitions in order to inform the development of regulations and interventions that lead to more effective use of e-cigarettes for smoking cessation. The findings suggest that interventions should focus on increasing motivation to quit smoking, addressing e-cigarette dependence, and promoting the sensory, social, and emotional benefits of e-cigarettes for smoking cessation. additionally, interventions should consider addressing cigarette dependence and spousal smoking as barriers to cigarette cessation for dual users.

Shafie-Khorassani F, Piper ME, Jorenby DE, et al. associations of Demographics, Dependence, and Biomarkers With Transitions in Tobacco Product Use in a Cohort of Cigarette Users and Dual Users of Cigarettes and E-cigarettes. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2023;25(3):462-469. doi:10.1093/ntr/ntac207