Classification, Perception, and Toxicity of Emerging Flavored Oral Nicotine Pouches

Introduction:
This article provides an in-depth analysis of the classification, perception, and toxicity of emerging flavored oral nicotine pouches (ONPs). Readers will learn about the different flavors and brands of ONPs available in the US and European markets, the most popular flavors, and the potential molecular targets and toxicities associated with exposure to ONPs.

Key Points:

* The study analyzed 152 snus and 228 synthetic ONPs, classifying them into 8 flavor categories: Tobacco, Menthol/Mint, Fruity, Candy/Deserts, Drink, aroma, Spices, and Mixed Flavors.
* The most popular flavors among snus ONPs are tobacco and menthol, while among synthetic ONPs, fruity and menthol are the most prominent flavors.
* Both snus and synthetic ONPs contain various concentrations of nicotine and other flavoring chemicals, including coolant WS-23.
* Exposure to ONPs can activate several signaling cascades, including the aKT and NF-kappaB pathways, which may lead to apoptosis and epithelial mesenchymal transition (EMT).
* The study highlights the importance of regulating ONPs, particularly in relation to their marketing and the availability of certain flavors that may appeal to young people.

Main Message:
The study underscores the need for further research into the potential health risks associated with exposure to ONPs. The marketing of ONPs with various flavor profiles, particularly those containing tobacco/menthol/fruit flavors, is likely to have regulatory and marketing disclaimers. It would be logical to determine how the market reacts in terms of compliance and non-compliance with flavor restrictions by regulatory agencies. The findings of this study could be used to notify potential policies and crystalize future research directions regarding ONPs flavors.

Shaikh, S. B., Newton, C., Tung, W. C., Sun, Y., Li, D., Ossip, D., & Rahman, I. (2023). Classification, Perception, and Toxicity of Emerging Flavored Oral Nicotine Pouches. International Journal of Environmental Research and Public health, 20(5), 4526. https://doi.org/10.3390/ijerph20054526