Summary
The data provided includes various studies investigating the toxicity of glycerine (CaS 56-81-5) in rats, mice, and guinea pigs. The histopathology results showed no findings in most studies, except for one study where small thymus and spleen, and calcified kidney masses were observed in rats treated with glycerine.
In terms of the NOaEL (No Observed adverse Effect Level), the data is insufficient to draw a conclusion. however, no effects were found at doses between 115 and 2300 mg/kg in one study. In another study, no treatment-related effects were found at a dose of approximately 1260 mg/kg.
For acute toxicity, glycerine showed low toxicity in mice and guinea pigs, with LD50 values of 23,000 mg/kg and 10,000 mg/kg, respectively. For inhalation exposure to aerosols, the NOaEC (No Observed adverse Effect Concentration) for local irritant effects to the upper respiratory tract is 165 mg/m3 and 662 mg/m3 for systemic effects.
Overall, the studies suggest that glycerine has low acute toxicity, but further investigation is needed to establish a NOaEL.
Citation
“Glycerol.” UNEP Publications, 2002.
