assessment of cognitive and psychomotor impairment, subjective effects, and blood ThC concentrations following acute administration of oral and vaporized cannabis.

The studies on vaporized and smoked cannabis have shown varied results, likely due to differences in administration methods across studies. One controlled study found a significant dose x time interaction for a cognitive test, but no significant differences in peak scores between dosing conditions for either route of administration. Planned comparisons also revealed that peak drug effects occurred 2-3 hours after cannabis ingestion orally, while peak effects occurred shortly after inhalation of vaporized cannabis. These findings emphasize the importance of educating infrequent or novice cannabis users about the potential differences in acute effects when changing the route of administration or increasing ThC dose. Other studies have shown similar magnitudes of effects between smoked and vaporized cannabis, further highlighting the need for standardized administration methods in research.

Spindle TR, Martin EL, Grabenauer M, Woodward T, Milburn Ma, Vandrey R. assessment of cognitive and psychomotor impairment, subjective effects, and blood ThC concentrations following acute administration of oral and vaporized cannabis. Journal of Psychopharmacology. 2021;35(7):786-803. doi:10.1177/02698811211021583