association of Cigarette and Electronic Cigarette Use Patterns With Levels of Inflammatory and Oxidative Stress Biomarkers among US adults: Population assessment of Tobacco and health Study.

Introduction:
This text summarizes a study examining the relationship between cigarette and electronic cigarette use patterns and levels of inflammatory and oxidative stress biomarkers in a nationally representative sample of US adults. The study aims to contribute to the understanding of the cardiovascular toxicity of e-cigarettes.

Key Points:

* The study used data from the Population assessment of Tobacco and health (PaTh) Study, a nationally representative longitudinal cohort in the US.
* Participants were classified into four categories based on cigarette/e-cigarette use behaviors in the past 30 days: non-use, exclusive e-cigarette use, exclusive cigarette use, and dual use.
* The study selected biomarkers of inflammation (hsCRP, IL-6, fibrinogen, sICaM) and oxidative stress (urinary 8-isoprostane) as dependent variables.
* Multivariable linear models with sequential adjustments for covariates were used to evaluate the association of cigarette/e-cigarette use behaviors with each biomarker.
* The study found that exclusive e-cigarette use had significantly lower levels of almost all inflammatory and oxidative stress biomarkers compared with exclusive smoking.
* There was no difference in biomarker concentration between participants who used e-cigarettes and non-users.
* Exclusive smoking and dual use had higher levels across all biomarkers compared with non-use.

Main Message:
The study suggests that exclusive e-cigarette use is associated with lower levels of inflammatory and oxidative stress biomarkers compared with exclusive smoking. These findings highlight the potential health benefits of completely replacing cigarette smoking with e-cigarettes or quitting the use of both products for cigarette smokers. however, it is important to note that the study does not suggest that e-cigarette use is safe, and further research is needed to fully understand the cardiovascular toxicity of e-cigarettes.

Stokes aC, Xie W, Wilson aE, et al. association of Cigarette and Electronic Cigarette Use Patterns With Levels of Inflammatory and Oxidative Stress Biomarkers among US adults: Population assessment of Tobacco and health Study. Circulation. 2021;143(8):869-871. doi:10.1161/CIRCULaTIONaha.120.051551