a comparative assessment of e-cigarette aerosol extracts and tobacco cigarette smoke extracts on in vitro endothelial cell inflammation response.

Introduction:
This text summarizes a research article that compares the effects of electronic cigarettes (e-cigarettes) and traditional tobacco cigarettes on human umbilical vein endothelial cells (hUVECs). The study measures cell viability, apoptosis, and the release of inflammation cytokines and adhesion molecules in response to treatment with e-cigarette aerosol extracts (ECa) and cigarette smoking extracts (CS). The text also discusses the implications of these findings for cardiovascular health and the potential of e-cigarettes as a harm reduction measure.

Key points:

* The study used hUVECs treated with ECa or CS with different nicotine concentrations.
* The CS (nicotine concentration at 0.125 μg/mL) decreased the viability of hUVECs by 71%, but not the four kinds of ECa.
* The apoptotic ratio was about 32.5% in the CS group, while it was lower in the ECa groups.
* Levels of adhesion molecules and inflammation cytokines were higher in the CS groups compared to the ECa groups.
* The four kinds of e-cigarettes induced significantly less cytotoxicity than the commercially available tobacco cigarettes in hUVECs.
* The CS showed the most severe impact on hUVECs.
* ECa might provide a harm reduction measure, especially in cardiovascular risk, after people switch from tobacco cigarettes to e-cigarettes.

Main message:
The study suggests that e-cigarettes may be less harmful to hUVECs than traditional tobacco cigarettes, as they induced significantly less cytotoxicity and had less severe impacts on cell viability, apoptosis, and the release of adhesion molecules and inflammation cytokines. These findings support the potential of e-cigarettes as a harm reduction measure, particularly in relation to cardiovascular risk. however, further research is needed to fully understand the long-term health effects of e-cigarette use.

Su L, Zhao M, Ma F, et al. a comparative assessment of e-cigarette aerosol extracts and tobacco cigarette smoke extracts on in vitro endothelial cell inflammation response. human & experimental toxicology. 2022;41:9603271221088996. doi:10.1177/09603271221088996