Summary
Introduction:
This article reviews the epidemiology of nicotine and suicide, the pharmacology of nicotine, and the relationship between smoking and suicide risk. The authors discuss the potential role of nicotine in increasing impulsivity and sensitization, which can contribute to suicidal behavior. They also explore the potential relationship between nicotine and other risk factors for suicide, such as stress and negative affect.
Key Points:
* Smoking is associated with increased suicide risk in current and former smokers, with the risk increasing proportionally with the number of cigarettes smoked per day.
* Nicotine inhalation can increase impulsivity and sensitization, which can contribute to suicidal behavior.
* Nicotine can interact with other risk factors for suicide, such as stress and negative affect, to increase the risk of suicidal behavior.
* Nicotine exposure during adolescence may increase the risk of early smoking onset and subsequent suicidal behavior.
* Nicotine delivery methods, such as electronic cigarettes, can also contribute to the risk of nicotine addiction and suicidal behavior.
Main Message:
The study highlights the complex relationship between nicotine and suicide risk, and the potential role of nicotine in increasing impulsivity and sensitization. The authors suggest that preventing early nicotine inhalation and reducing sensitization may be effective strategies for reducing suicide risk. additionally, the study emphasizes the importance of considering nicotine exposure and delivery methods when assessing suicide risk, particularly in adolescents. Overall, the study underscores the need for further research on the relationship between nicotine and suicide risk, and the potential for targeted interventions to reduce the risk of suicidal behavior.
Citation
Swann aC, Graham DP, Wilkinson aV, Kosten TR. Nicotine Inhalation and Suicide: Clinical Correlates and Behavioral Mechanisms. The american journal on addictions. 2021;30(4):316-329. doi:10.1111/ajad.13171
