hazardous Compounds in Tobacco Smoke

Introduction:
This text provides an in-depth analysis of tobacco smoke components and their hazardous effects on human health. The authors have developed an up-to-date list of hazardous tobacco smoke components together with inhalation risk values covering all major tobacco-related diseases. The study also establishes thresholds of toxicological concern (TTC) for tobacco smoke components. Readers will learn about the methodology used to create the list of hazardous smoke components, the components included in the list, and the TTC thresholds established for tobacco smoke.

Key Points:

* The study generated a database of 2,256 different smoke components, with 542 of them having yield levels per cigarette in mainstream smoke.
* The authors found inhalation risk values for 98 components, which were selected for the list of hazardous smoke components.
* The list includes all nine components reported in mainstream cigarette smoke that are known human carcinogens and all nine components that are probably carcinogenic to humans.
* The authors derived two TTCs, one for all risk values including carcinogens (0.0018 µ g day−1) and one for endpoints other than carcinogenicity (1.2 µ g day−1).
* The list of hazardous smoke components can be used for regulatory purposes like the progressive reduction in the level of toxic chemicals in tobacco product emissions.
* The authors recommend replacing the hoffmann list with the current list of hazardous smoke components.
* The TTC thresholds can be used to exempt components with emission levels below these thresholds from further hazard consideration.

Main Message:
The study provides a comprehensive list of hazardous tobacco smoke components and thresholds of toxicological concern (TTC) for tobacco smoke components. The list of hazardous smoke components can be used for regulatory purposes like the progressive reduction in the level of toxic chemicals in tobacco product emissions. The TTC thresholds can be used to exempt components with emission levels below these thresholds from further hazard consideration. Overall, the study highlights the importance of regulating tobacco products and provides a scientific basis for such regulation.

Talhout, Reinskje, Thomas Schulz, Ewa Florek, Jan Van Benthem, Piet Wester, and antoon Opperhuizen. “hazardous Compounds in Tobacco Smoke.” International Journal of Environmental Research and Public health 8, no. 2 (February 23, 2011): 613–28. https://doi.org/10.3390/ijerph8020613.