Summary
Introduction:
This text is a summary of a scientific study examining the effect of nicotine form (free-base vs protonated) on nicotine yield and the amount of liquid aerosolized while varying electrical power and liquid vehicle in electronic cigarettes (ECIGs). The study aims to provide insight into the relationship between nicotine form and ECIG performance, which is relevant for regulations aiming to limit nicotine delivery.
Key points:
* The study found that nicotine yield was not significantly associated with nicotine form, but was strongly associated with power and PG/VG ratio.
* The regression model explained 93% of the variance in nicotine yield, and nicotine yield can be predicted accurately from the product of TPM and the liquid nicotine concentration.
* The nicotine form in the ECIG aerosol corresponds to that of the liquid, but form does not impact yield. It likely affects user sensory experience, such as the "throat hit" of the inhaled aerosol.
* The liquid vehicle and power have a strong effect on ECIG performance, with PG-based liquids resulting in higher nicotine yield than VG liquids.
* The study speculates that nicotine form may play a role in nicotine delivery to the blood and puffing behavior, which could influence exposure.
Main message:
The study highlights that nicotine form does not affect nicotine yield, but likely affects nicotine delivery and puffing behavior. Regulations aiming to limit nicotine delivery from ECIGs must consider not only nicotine concentration, but also liquid vehicle and device power. The study also emphasizes the need for controlled clinical studies to further investigate the impact of nicotine form on puffing behavior and exposure.
Citation
Talih S, Salman R, El-hage R, et al. Effect of free-base and protonated nicotine on nicotine yield from electronic cigarettes with varying power and liquid vehicle. Scientific reports. 2020;10(1):16263. doi:10.1038/s41598-020-73385-6
