Summary
This document is a research article titled "DNa damage, DNa repair and carcinogenicity of tobacco products: a comprehensive review" published in the journal Tobacco-induced diseases in 2022. The authors conducted a comprehensive review of existing literature on the DNa damage and carcinogenicity caused by various tobacco products, including conventional cigarettes, e-cigarettes, and heat-not-burn tobacco products. The review also covers the DNa repair mechanisms that are activated in response to tobacco-induced DNa damage.
The article summarizes findings from multiple studies, some of which are referenced in this document. For example, the authors cite results from Weng et al. (20) and Lee et al. (19) that show the chemical composition of cigarette smoke and e-cigarette aerosol. The document also includes data from various studies that measured DNa adduct formation, DNa damage, and DNa repair in response to tobacco exposure.
The researchers found that tobacco smoke contains numerous chemicals that cause DNa damage, including polycyclic aromatic hydrocarbons (Pahs), aromatic amines, and tobacco-specific nitrosamines (TSNas). E-cigarette aerosol was found to contain lower levels of these harmful chemicals compared to cigarette smoke, but still contains some DNa-damaging compounds.
The document also highlights the importance of DNa repair mechanisms in preventing cancer development. The authors explain that DNa repair pathways, such as base excision repair (BER), nucleotide excision repair (NER), and double-strand break repair (DSBR), are activated in response to tobacco-induced DNa damage. however, the efficiency of these DNa repair mechanisms can be compromised by continued exposure to tobacco products.
In summary, this document provides a comprehensive review of the DNa damage and carcinogenicity caused by various tobacco products, as well as the DNa repair mechanisms that are activated in response to tobacco exposure. The authors found that tobacco smoke contains numerous DNa-damaging chemicals, while e-cigarette aerosol contains lower levels of these harmful compounds. The review emphasizes the importance of DNa repair mechanisms in preventing cancer development and highlights the need for further research in this area.
Citation
Tang MS, Lee hW, Weng MW, et al. DNa damage, DNa repair and carcinogenicity: Tobacco smoke versus electronic cigarette aerosol. Mutation research Reviews in mutation research. 2022;789:108409. doi:10.1016/j.mrrev.2021.108409
