Summary
Introduction:
This text is a meta-analysis of randomized clinical trials evaluating the effectiveness of smoking cessation interventions in people with peripheral artery disease (PaD). The analysis aimed to determine the overall impact of various interventions on smoking cessation rates in this population. The key points and main message of the text are summarized below.
Key Points:
* The analysis included six randomized clinical trials with a total of 558 smokers with PaD.
* The interventions tested included physician advice, behavioral counseling, and the provision of nicotine replacement therapy and/or varenicline.
* a meta-analysis of the trials suggested that these interventions did not significantly increase the chance of quitting smoking (RR, 1.48; 95% CI, 0.84-2.61), with low heterogeneity between studies (I2ΒΌ20%).
* Risk of bias was high, moderate, and low in one, three, and two studies, respectively.
* a funnel plot suggested a low risk of publication bias.
* Previous smoking cessation interventions have not been effective in achieving smoking cessation in people with PaD.
* Further research is needed to develop and test interventions that can effectively help current smokers with PaD to quit.
Main Message:
The meta-analysis found that currently available smoking cessation interventions have not been effective in helping people with PaD to quit smoking. Given the high prevalence of smoking in this population and its association with increased risk of atherosclerosis progression, failure of lower-limb revascularization, and amputation, there is a critical need for the development and testing of effective interventions to help people with PaD quit smoking.
Citation
Thanigaimani S, Drovandi a, Golledge J. a meta-analysis of randomized controlled trials evaluating the efficacy of smoking cessation interventions in people with peripheral artery disease. Journal of vascular surgery. 2022;75(2):721-729.e7. doi:10.1016/j.jvs.2021.07.248
