Simultaneous extraction and surface enhanced Raman spectroscopy detection for the rapid and reliable identification of nicotine released from snus products

Introduction:
This article presents a study on the development of a rapid and reliable method for identifying nicotine released from snus products using surface enhanced Raman spectroscopy (SERS) and simultaneous extraction in a capillary system. The study aims to provide a new tool for the evaluation of snus products and to establish a method for the rapid evaluation of the processing and selection of excipients of snus products.

Key Points:

* The study utilizes a nano-au assembly hierarchy structure in a capillary for the simultaneous extraction and SERS detection of nicotine.
* The time evolution of the concentrations of nicotine released from snus products was measured and the concentration of nicotine released decreased significantly over time.
* Data fitting revealed an obvious quadratic relationship between the concentration of nicotine and time.
* The release of most of the nicotine in the snus pouch was completed after approximately 24.15 minutes.
* The method provides a new idea for the further study of the production of snus pouches and related tobacco products.
* The study also highlights the potential of the method for assessing the distribution of major nicotinoids over time, which could improve understanding of their release in the respiratory tract and impact on smokers' health and cessation programs.

Main Message:
The study demonstrates the potential of using SERS and simultaneous extraction in a capillary system for the rapid and reliable identification of nicotine released from snus products. The results provide valuable information for the evaluation of snus products, and the method has the potential for assessing the distribution of major nicotinoids over time, which could have significant implications for understanding their impact on smokers' health and cessation programs. The development of this method could also lead to new ideas for the further study of the production of snus pouches and related tobacco products.

Tian, Y., Tang, X., Fu, Y., Shang, S., Dong, G., Li, T., huang, X., & Zhu, D. (2021). Simultaneous extraction and surface enhanced Raman spectroscopy detection for the rapid and reliable identification of nicotine released from snus products. analytical Methods: advancing Methods and applications, 13(46), 5608–5616. https://doi.org/10.1039/d1ay01601f