Summary
Based on the information provided, the following summarized health effects of Propylene Glycol can be derived:
1. Ingesting high doses of Propylene Glycol (3,000 mg/kg and 1,400 mg/kg/day) has been associated with adverse health effects in animal studies (Bauer et al. 1992).
2. Ethylene glycol intoxication in dogs and cats can lead to oxalate nephrosis, which may be diagnosed through ultrasonographic findings (adams et al. 1991, 1989; Thrall et al. 1984).
3. Propylene Glycol can cause skin irritation and sensitization, but this can be reduced by cleaning the skin with a defatting solvent and washing with water (Trancik and Maiback 1982).
Note that these findings are based on animal studies and may not directly apply to humans. The human equivalent of the significant exposure levels would require additional information and calculations.
Citation
Murray, Ed, and Julia George. “Toxicological Profile for Propylene Glycol.” agency for Toxic Substances and Disease Registry, USDhhS, September 1997.
