Summary
Introduction:
This text is a summary of a randomized controlled trial that aimed to measure systemic nicotine delivery from various types of vaporized nicotine products (VNPs), assess initial perceptions of various types of VNPs, assess subjective effects after one-week of experimentation with each device, and assess possible interplay between these factors. The study design and major points are summarized below:
Key Points:
* The study included 18 nicotine dependent, daily, regular adult cigarette smokers who were randomized to the order of six different VNPs: disposable, rechargeable, eGO, mod, e-Cigar, and e-Pipe.
* Each device was tested using a smoking machine to determine an average nicotine yield in 20 puffs, and devices with the lowest within-brand variability were chosen.
* Participants underwent a controlled puffing session using the assigned device for 10 minutes, and blood samples were taken to assess the individual’s nicotine pharmacokinetic profiles.
* Participants also completed questionnaires pertaining to the subjective effects of nicotine delivered by the tobacco cigarette and VNPs, and rated their satisfaction with and helpfulness of each VNP following product use.
* The study found that the eGO and mod models have properties that may make them most effective for cigarette substitution among smokers who intend to switch to a VNP.
Main Message:
The study provides important insights into the systemic nicotine delivery, initial perceptions, and subjective effects of various types of VNPs. The results suggest that the eGO and mod models have properties that may make them most effective for cigarette substitution among smokers who intend to switch to a VNP. These findings can inform regulatory decisions regarding the use and marketing of VNPs. It is important to continue to study the characteristics of VNPs that could both facilitate and hinder a tobacco cigarette smoker attempting to transition to a VNP for harm reduction purposes.
Citation
Voos N, Kaiser L, Mahoney MC, et al. Randomized within‐subject trial to evaluate smokers’ initial perceptions, subjective effects and nicotine delivery across six vaporized nicotine products. addiction. 2019;114(7):1236-1248. doi:10.1111/add.14602
