adverse effects of E-cigarettes on head, neck, and oral cells: a systematic review.

Introduction:
This text provides an in-depth analysis of a systematic review examining the adverse effects of e-cigarettes on head, neck, and oral cells. The review aimed to determine whether e-cigarettes cause harm to these cells and if they can be considered a safe alternative to traditional cigarettes. The text includes details about the study design, major findings, and the main message of the review.

Key Points:

* The review included 18 articles, with 16 of them conducted in vitro and two clinical trials.
* Seven studies were conducted in the US, two in Canada, two in Switzerland, three in Germany, two in Italy, one in Poland, and one in Brazil.
* Four studies examined e-cigarette liquid on oral cells, nine e-cigarette vapor, four tested cigarette liquid and vapor, and one study the effects of vapor on DNa.
* Nicotine concentration ranged from 0 to 24 mg/ml, and 12 flavors were tested for toxicity.
* human gingival fibroblasts (hGF’s) were used in 6 studies, five studies used oral epithelial cells (OEC’s), one study used oral pharyngeal cells, one study used oral keratinocytes, and two studies used premalignant keratinocytes, lymph cells, and head and neck squamous epithelial cells.
* Eight studies used donor tissue to create cell lines, eight studies used cultured cell lines, and two studies used research participants.
* Most articles found cigarette smoke to be significantly more toxic to head, neck, and oral cells than e-cigarettes.

Main Message:
The main message of this systematic review is that e-cigarettes are not as safe as marketing suggests. While e-cigarettes may be less toxic than traditional cigarettes, they still cause adverse effects on head, neck, and oral cells. The review highlights the need for more research to determine the long-term effects of e-cigarette use, especially in chronic users. healthcare professionals should also be aware of the potential risks associated with e-cigarette use and educate their patients accordingly. It is crucial to regulate e-cigarettes properly to protect public health and prevent nicotine addiction in young people.

Wilson C, Tellez Freitas CM, awan Kh, ajdaharian J, Geiler J, Thirucenthilvelan P. adverse effects of E-cigarettes on head, neck, and oral cells: a systematic review. Journal of oral pathology & medicine : official publication of the International association of Oral Pathologists and the american academy of Oral Pathology. 2022;51(2):113-125. doi:10.1111/jop.13273