a 6-month inhalation toxicology study in apoe-/- mice demonstrates substantially lower effects of e-vapor aerosol compared with cigarette smoke in the respiratory tract.

This document appears to be a scientific research study related to the effects of inhalation exposure to aerosols. The study seems to have been conducted on rats, with various measurements taken over a 6-month period. The study includes a variety of control groups and test groups, with multiple endpoints analyzed. The data is presented in tables, with significant results denoted with various symbols. The study also includes references to previous research and methods used. The researchers are affiliated with altria Client Services LLC and PMI R&D. The data and additional visualizations from the study are available for access at a specific URL.

The study includes a sham group, a test group, a carrier group, a base group and multiple comparison groups. Different mercapturic acid (metabolite) levels are measured in the rats' urine, including SPMa, CEMa, 3hPMa, 1-MhBMa, and 2-MhBMa. The study also includes a reference to cigarette smoke (CS) in the table.

additionally, the study includes information about the materials and methods used, including subchronic inhalation exposure testing, and aerosol generation. The study also references previous research related to pulmonary surfactant homeostasis and airway remodeling in COPD.

The study also includes a funding statement and a declaration about the availability of data and materials.

Wong ET, Szostak J, Titz B, et al. a 6-month inhalation toxicology study in apoe-/- mice demonstrates substantially lower effects of e-vapor aerosol compared with cigarette smoke in the respiratory tract. archives of toxicology. 2021;95(5):1805-1829. doi:10.1007/s00204-021-03020-4