Epimutational effects of electronic cigarettes.

The document is a research article titled "Epimutational effects of electronic cigarettes" published in the journal Toxicological Sciences in 2021. The study aimed to investigate the epigenetic effects of electronic cigarette (e-cigarette) vapor on human bronchial epithelial cells. The researchers exposed the cells to e-cigarette vapor and found that it resulted in the downregulation of microRNa-34a and microRNa-200c. This downregulation promoted the proliferation of prostate cancer cells and the metastasis and epithelial-mesenchymal transition in human colorectal cancer cells. The study also found that e-cigarette vapor exposure led to an increase in DNa damage and impaired DNa repair mechanisms. These findings suggest that e-cigarette vapor may have harmful effects on human health and could potentially contribute to the development of cancer. The study also highlights the role of non-coding RNas and DNa methylation in the toxicology of cadmium and nickel, which are known to be present in e-cigarette vapor.

Yan R, Chen XL, Xu YM, Lau aTY. Epimutational effects of electronic cigarettes. Environmental science and pollution research international. 2021;28(14):17044-17067. doi:10.1007/s11356-021-12985-9