Time course of changes in inflammatory and oxidative biomarkers in lung tissue of mice induced by exposure to electronic cigarette aerosol.

Introduction:
This text summarizes a scientific study examining the effects of electronic cigarette (e-cigarette) aerosol exposure on inflammation and oxidative stress in the lungs of mice. The study aimed to investigate the time course of these effects at various time points (one, two, and four weeks of exposure) using a liquid containing no flavorants or additives.

Key Points:

* The study exposed Balb/c mice to e-cigarette aerosols for 1 h/day for 1, 2, or 4 weeks and compared them to sham-exposed controls.
* Exposure to e-cigarette aerosols increased total inflammatory cells, eosinophils, macrophages, and TNFα levels in the lung tissue after 1, 2, and 4 weeks of exposure.
* Neutrophils and basophils significantly increased after 1 week of exposure, and IL-10 levels decreased significantly after 1 week of exposure.
* Exposure to e-cigarette aerosols decreased the GSh/GSSG ratio and GPx levels after 2 and 4 weeks of exposure, and catalase activity after 4 weeks of exposure.
* TBaRS levels showed a trend of elevation with time and reached a significant elevation after 4 weeks.

Main Message:
The study suggests that inhalation of unflavored e-cigarette aerosol may be associated with inflammation in lung tissue that worsens as the duration of exposure increases. The findings highlight the potential harmful health effects of e-cigarettes on the lungs, even in the absence of flavorants or other additives. Further experiments are needed to confirm these results and investigate the specific molecules that may mediate the observed airway inflammation.

alzoubi Kh, Khabour OF, al-Sawalha Na, Karaoghlanian N, Shihadeh a, Eissenberg T. Time course of changes in inflammatory and oxidative biomarkers in lung tissue of mice induced by exposure to electronic cigarette aerosol. Toxicology reports. 2022;9:1484-1490. doi:10.1016/j.toxrep.2022.07.001